Strain Differences Associated with Refractory Lyme Arthritis

One strain of Borrelia burgdorferi appears to be more frequent in patients with antibiotic-refractory Lyme arthritis, researchers say.

“Our results add to the emerging literature concerning the differential pathogenicity of strains of B. burgdorferi,” the researchers said.

The tick-borne spirochete causes Lyme disease, which often begins with erythema migrans, an expanding skin lesion. The spirochetes frequently disseminate within a week to the nervous system, heart, and joints, often promoting arthritis.

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Greater Understanding Of Lyme Disease-causing Bacteria

Lyme disease in the U.S. is caused by the tick-borne bacteria Borrelia burgdorferi and usually begins with a skin lesion, after which the bacteria spread throughout the body to the nervous system, heart or joints. About 60 percent of untreated individuals develop arthritis, which affects the knees in particular.

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